Djokovic knocked out of US Open in shock first-round loss

Novak Djokovic has been knocked out of the U.S. Open in the opening round.

The 39-year-old lost in five sets to Argentinian world No. 49 Mariano Navone (7-6, 5-7, 4-6, 6-2, 6-1).

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It's the first time Djokovic has lost in the first round at any major since the 2006 Australian Open.

He will now have to wait until the Australian Open in January for another chance at a record 25th Grand Slam title.